The CTL responses elicited by vaccination of mice with T7-p66 nanoparticles showed superior anti-tumor effects in vivo over p66 peptide-CFA/IFA emulsion indicated by a higher survival of mice (83% vs. 33%) against HER-2-expressing TUBO cell challenge and complete regression of the established tumors (66% vs. 33%). Here, ERBB2 is linked to neoplasm.