Immunization of mice with murine pneumotropic virus (MPtV) or murine polyomavirus (MPyV) VLPs carrying an ECD-TM (extracellular plus transmembrane domain) fragment of rat HER-2/neu was efficient both as a prophylactic and therapeutic tumor vaccine against rat HER-2-positive TUBO tumors [32], [33]. Here, ERBB2 is linked to neoplasm.