It has been previously reported that co-administration of a dominant H2-Kd-restricted CTL epitope of rat HER-2 (p66 peptide) with incomplete Freund’s adjuvant (IFA) and TLR9 agonist CpG ODN 1826 induced immune responses with prophylactic and therapeutic benefit against spontaneous mammary tumors in BALB-neuT transgenic mice [20]. Here, TLR9 is linked to breast cancer.