It’s anti-obesity mechanism involves the down-regulation of the major transcription factors of the adipogensis pathway including PPAR-γ and C/EBP-α by regulation of Akt and ERK1/2 pathway, and resultant down-regulation of lipid metabolizing enzymes, FAS, LPL and aP2 which are involved in the transport, uptake and synthesis of lipids needed for the accumulation of lipid in adipocytes. Here, MAPK3 is linked to obesity due to melanocortin 4 receptor deficiency.