FBXW7 and cancer: These observations demonstrated that FBXW7 is a human tumor suppressor gene, a conclusion that is also supported by the discovery of FBXW7 gene mutations in cancers from a wide spectrum of human tissues, such as bile duct, blood, bone, brain, breast, colon, endometrium, stomach, lung, ovary, pancreas, and prostate, with overall 6% point mutation frequency [17].