For this purpose, we used breast cancer data, collected during the time period of 2004–2008 in the 17 registry set of the National Cancer Institute's Surveillance Epidemiology and End Results (SEER17) database [41], which was the most recent SEER-based breast cancer data (containing information on ER and PR status) available at the time of this work. The gene discussed is ESR1; the disease is breast cancer.