To further assess the associations of ERCC1 and ERCC4 polymorphisms with gastric cancer risk, we conducted a case-control study by genotyping five potential functional SNPs, three in ERCC1 and two in ERCC4, in an Eastern Chinese Han population of 1125 gastric cancer cases and 1196 cancer-free controls. The gene discussed is ERCC1; the disease is gastric cancer.