RHOA and hepatocellular carcinoma: However, rs11716445, the SNP that defines the H3B haplotype, is located in a rare 45 bp cryptic exon (referred to as RHOA exon 2.5) that we identified in multiple unique sequences during RNA-Seq analysis of three human hepatoma cell lines (HepG2, Hep3B and Huh7), and CAP LCLs (n = 3), Figure 4A.