CPAP and Seckel syndrome: Without a complete examination of the effects of different CENPJ-mutations on mRNA levels and splicing, and CENPJ protein levels, it is difficult to say why CENPJ mutations can either result in primary microcephaly or Seckel syndrome, or why the Cenpjtm1a(EUCOMM)Wtsi allele results in a mouse with a Seckel syndrome-like phenotype.