CPAP and microcephaly: The CENPJ-microcephaly mutations reported to date affect exons 2 (17delC), 11 (3243–3246delTCAG) and 16 (A3704T) [14], [15]; these mutations are predicted, but not proven, to cause defects in spindle pole orientation and proliferation of neural progenitors in a similar manner to other microcephaly genes.