RELA and asthma: In asthma exacerbations, increased airway inflammation is strongly associated with clinical illness severity (Message et al, 2008; Papi et al, 2006; Wark et al, 2002) and this is thought to be mediated by NF-κB p65 activation, although studies directly demonstrating activated NF-κB p65 during RV infection or RV-induced asthma exacerbations in vivo are yet to be reported.