PIK3CA and cervical squamous intraepithelial neoplasia: In order to define new genetic pathways of colorectal carcinogenesis, we sought evidence for the primary drivers of the associations between somatic mutations (KRAS, NRAS, BRAF, PIK3CA, TP53, FBXW7), CIN, MSI and the three sites of LOH (see Supplementary material, Tables S2, S3).