In order to define new genetic pathways of colorectal carcinogenesis, we sought evidence for the primary drivers of the associations between somatic mutations (KRAS, NRAS, BRAF, PIK3CA, TP53, FBXW7), CIN, MSI and the three sites of LOH (see Supplementary material, Tables S2, S3). The gene discussed is KRAS; the disease is cervical squamous intraepithelial neoplasia.