The AUC of using IGFBP-2 as diagnostic biomarker for lung cancer was 0.608 (95% CI=0.504–0.712, p=0.047), the sensitivity and specificity were 54.1 and 72.5%, respectively, with the cutoff value of 1,173.033 ng/ml. This evidence concerns the gene IGFBP2 and lung carcinoma.