PRNP and neurodegenerative disease: Does translational repression contribute to the pathophysiology of neurodegenerative diseases? The role of the SG pathway in translational repression also raises inherent questions about the role of translation repression in the pathophysiology of disease; the ability of GADD34 to delay progression of PrP mediated degeneration emphasizes the potential significance for therapy of neurodegenerative diseases [51].