Among the RA cases, the overall mean ± standard deviation age was 48 ± 11.6 years, 86.3% were female, 64.5% were ACPA-positive, 40.1% were HLA-DRB1 SE-positive, and 51.5% were rheumatoid factor-positive. The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.