PADI4 and rheumatoid arthritis: The meta-analysis also revealed a significantly increased OR (ORoverall = 1.20, 95% CI = 1.01 to 1.44, P = 0.04) when applying a dominant/recessive genotype model for the PADI4 rs2240340 variant, suggesting that the PADI4 is associated with RA in the Malaysian population of Asian descent.