POU5F1 and Infertility: In view of the concept of the beneficial effect of granulosa cells on oocyte maturation, the need for greater understanding of the mechanisms involved in late oogenesis and the need for independent prognostic markers of better outcomes using conventional IVF for couples with non-male factor infertility, we focused on Oct-4 and DAZL as target genes in luteinized granulosa cells of the human ovaries.