CD8A and neoplasm: Furthermore, pre-treatment of MSC with IFNγ (within a moderate range) upregulates MHC-I and II expression and improves antigen phagocytosis and presentation capabilities, thereby stimulating CD4 and CD8 T-cell proliferation and generation of anti-tumor CD8+ cytotoxic T-lymphocytes (CTLs) (Majumdar et al., 2003; Chan et al., 2006; Stagg, 2007; Francois et al., 2009; Schena et al., 2010).