As described previously, the therapeutic effect of racotumomab-alum was associated to an increase of CD4+ and CD8+ T cell infiltration, a reduced angiogenesis and tumor cell apoptosis in lung nodules, although measurable antibodies were not detected against purified NeuGcGM3 by ELISA assay in C57BL/6 mice (Diaz et al., 2009). This evidence concerns the gene CD4 and neoplasm.