A fusion protein consisting of 38C13 murine B cell lymphoma scFv and tetanus toxin fragment C (FrC), produced in E. coli as inclusion bodies or using a cell-free protein synthesis system, induced anti-Id antibodies and was as effective as the IgM-KLH Id protein in increasing survival after tumor challenge (Patel et al., 2011). The gene discussed is ID1; the disease is neoplasm.