On the contrary, in the 38C13 as well as in the A20 murine B cell lymphoma models, protection was found to be dependent on CD4+ and CD8+ T cells, when animals were vaccinated with a DNA construct encoding the scFv-Id fused to two different chemokines (Biragyn et al., 1999). Here, ID1 is linked to B-cell non-Hodgkin lymphoma.