In a contrasting result, the xenogeneic human IgG3 hinge/CH3 were required for good antibody responses and tumor protection in the murine MOPC315 myeloma and A20 B cell lymphoma models, with a DNA vaccine encoding the respective dimeric scFv-Id fused to the MIP-1α chemokine, administered by intramuscular injection followed by electroporation. The gene discussed is ID1; the disease is plasma cell myeloma.