Numerous data have proved that significantly higher AFP serum levels associated with various liver diseases, such as viral hepatitis, liver cirrhosis, and liver tumors (primarily HCC and hepatoblastoma, but also metastasis in 5%-10% cases), and other neoplasms, which are the most prevalent cancers of the digestive tract (pancreas ~24%, stomach ~15%, large intestine ~3%, and gallbladder). The gene discussed is AFP; the disease is liver disorder.