DNMT3A and lung carcinoma: Moreover, in lung cancer, miR-29 family miRs (29a, 29b, and 29c) directly target both DNMT3A and -3B, and over-expression of miR-29s in lung cancer cell lines restores normal patterns of DNA methylation, induces re-expression of methylation-silenced tumor suppressor genes and inhibits tumorigenicity in vitro and in vivo (Fabbri et al., 2007).