Firstly, while mechanistic studies have been performed to illustrate the role of miR methylation in the pathogenesis of certain lymphoma subtypes (such as methylation of miR-146a in NK-cell lymphoma, miR-230 in gastric MALT lymphoma, and miR-29a in ALK+ve ALCL), it is likely that multiple miRs may be hypermethylated in any single lymphoma subtype. This evidence concerns the gene ALK and anaplastic large cell lymphoma.