Although the NFκB-triggered positive-feedback-loop for IL-6-signaling (IL-6-amplifier) was originally discovered in mice to be a synergistic-activation signal that is activated following IL-17A and IL-6 stimulation in non-immune cells, results from disease models such as a rheumatoid arthritis, F759 mice, and EAE have shown that the IL-6-amplifier in fibroblasts, a type of endothelial cell, is activated by simultaneous stimulation of NFkB and STAT3 and locally induces chemokines and chronic inflammation. Here, NFKB1 is linked to rheumatoid arthritis.