Indeed, we have proposed a four-step model for MHC class II-associated autoimmune diseases: (1) T cell activation regardless of antigen specificity; (2) local events inducing a tissue-specific accumulation of activated T cells; (3) transient activation of the IL-6 amplifier; and (4) enhanced sensitivity to cytokines in the target tissue. The gene discussed is IL6; the disease is autoimmune disease.