In addition, it has also been proposed that GOAT by a specific inhibitor could be a potential treatment against obesity by inhibiting ghrelin acylation and consequently avoid weight gain (Gualillo et al., 2008; Yang et al., 2008; Gomez et al., 2009; Barnett et al., 2010). This evidence concerns the gene MBOAT4 and obesity due to melanocortin 4 receptor deficiency.