TP53 and pancreatic intraductal papillary-mucinous neoplasm: Similarly, molecular events including mutation of K-ras (Satoh et al., 1993b, 1996), inactivation of p53 (Satoh et al., 1996) or smad4 (Biankin et al., 2002) were demonstrated to be correlated with malignant BD-IPMN.