The ecto-5′-nucleotidase (5′-nucleotidase, ecto-5′-NT, CD73), overexpressed in the metastatic variant of the MDA-MB-435 cells (Leth-Larsen et al., 2009) has been shown to affect tumor growth by limiting the antitumor T-cell immunity via adenosine receptor signaling. This evidence concerns the gene NT5E and neoplasm.