As it is known that human gliomas and tumorigenic NSCs express SHH (Ehtesham et al., 2007) and comprise cells that simultaneously express neuronal and glial markers (Katsetos et al., 2001; Ignatova et al., 2002; Singh et al., 2003; Walton et al., 2009), this morphogene was associated with brain tumor formation and/or growth. This evidence concerns the gene SHH and brain neoplasm.