It seems necessary to identify, in clinical specimens such as blood, amniotic fluid, cerebrospinal fluid, and the placenta, the genetic alterations of TLR2, TLR4, and TLR9 genes accompanying the development of these infections and to describe the clinical significance of single-nucleotide polymorphisms (SNPs) residing in these genes in regard to congenital toxoplasmosis. This evidence concerns the gene TLR4 and congenital toxoplasmosis.