A low-frequency (MAF 3.5%) non-synonymous (R82C) polymorphism in CD300LG was associated with lower fasting levels of serum HDL-cholesterol while two common (MAF 12.5% and 23.4%, respectively) non-synonymous polymorphisms in COBLL1 and MACF1 were associated with type 2 diabetes (Table 2). The gene discussed is MACF1; the disease is type 2 diabetes mellitus.