After querying for the term 'estrogen' in InSilico DB, she selects three datasets for retrieval and analysis: (i) GSE20711 [45], a microarray dataset containing 87 samples from breast cancer patients with ER mutation status information (indicated as ER+ or ER-); (ii) GSE27003 [46], an RNA-Seq dataset with 8 samples from breast cancer-derived cell lines with ER+/ER- status; and (iii) ISDB6354, a subset of the C-MAP dataset containing the 13 MCF7 cell line samples that were treated with ER agonists or antagonists (the 'Grouping and sub-grouping' section explains how the subset is created). This evidence concerns the gene ESR1 and breast cancer.