In particular, we showed that in response to E-selectin activation, endothelial cell permeability and TEM of cancer cells are regulated by the formation of stress fibers by p38-dependent actin polymerization and myosin light chain phosphorylation and by ERK-dependent regulation of the VE-cadherin-βcatenin complex at the adherens junctions[5]. Here, MAPK1 is linked to cancer.