ELANE and infection: Figure 8 shows that recombinant neutrophil elastase significantly altered gut microbiota composition. A dendogram using Bray-Curtis metrics depicts that mice given recombinant neutrophil elastase had significantly different microbial profiles compared to untreated mice (Figure 8A). Furthermore, a heat map of the relative abundance of OTUs that were significantly affected by elastase (Figure 8B) shows that members of the same bacterial families (Ruminococcaceae and Lachnospiraceae) were eliminated or depleted in treated mice as those observed in the infection model.