CD8A and type 1 diabetes mellitus: In addition, the IGRP-specific CD8 T-cells from HLA-A2 Tg NOD mice lyse human HLA-A2+ beta-cells in-vitro, demonstrating the potential utility of HLA-A2 Tg NOD mice for identifying HLA-restricted islet autoantigens and for investigating the pathogenesis of human T1D [16].