Yet, the fact that IGRP265–273-reactive CD8 T-cells were present among the islet-specific CD8 T-cells, as well as the recent finding that specific targeting of IGRP-reactive CD8 T-cells effectively inhibited diabetes development in NOD.β2mnull.HHD mice [46] corroborate our current findings that this epitope is pathogenic in human disease. Here, CD8A is linked to diabetes mellitus.