While spontaneous relapses during R14-induced uveitis appear unpredictable, we observed rather synchronized recurrences of intraocular inflammation with clinical scores of 1–2 in 7 of 8 eyes 3 days after injection of IFN-γ (mean maximum scores of all eyes: 1.0), while only 1/8 eyes injected with saline experienced a relapse (mean score 0.125). This evidence concerns the gene IFNG and uveitis.