Significantly increased VPA sensitivity was seen after concomitant inhibition of tubulin polymerization by vincristine (VCR) (Figure 3C and D), actin polymerization by cytochalasin B (Figure 3E), or HSP90 by geldanamycin (GA) (Figure 3C and F) in the MOLM-13 and the MV4-11 AML cell lines (Figure S3). The gene discussed is HSP90AA1; the disease is acute myeloid leukemia.