Currently, many genes appear to be involved in the pathogenesis of ALS, including chromosome 9 open reading frame 72 (C9orf72), superoxide dismutase-1 (SOD1), angiogenin (ANG), fused in sarcoma/translated in liposarcoma (FUS/TLS), TAR DNA-binding protein 43 (TARDBP/TDP-43), vesicle-associated membrane protein B (VAPB), optineurin (OPTN), valosin-containing protein (VCP), ubiquilin-2 (UBQLN2), sequestosome-1 (SQSTM1), and profilin-1 (PFN1) [5], [6], [7], [8], [9], [10], [11]. The gene discussed is PFN1; the disease is amyotrophic lateral sclerosis.