CYP11A1 and polycystic ovary syndrome: Comparison of CYP11A1 promoter function in normal and PCOS theca cells showed that under both basal (a, P<0.01) and forskolin-stimulated (b, P<0.01) conditions, −2327, −1676, −660, and −160 CYP1A1 LUC activity was increased approximately 2-fold in PCOS theca cells, as compared to normal theca cells (Fig. 2B).