These data show that overexpression NF-1C in PCOS theca cells has the ability to decrease CYP11A1 transcription, and suggest that the previously reported increase in NF-1C levels observed in normal theca cells contribute to lowered levels of CYP11A1 expression which are phenotypic of the normal cycling ovary. Here, CYP11A1 is linked to polycystic ovary syndrome.