CYP11A1 and polycystic ovary syndrome: In addition, demonstrating increased −1676Δ−1540/−90 promoter regulation compared to the full length −1676 CYP11A1 promoter construct, further provide evidence to suggest that sequences between −1540 and −90 bp of the CYP11A1 promoter confer differential regulation in normal and PCOS theca cells (Fig. 3B).