In contrast, in PCOS theca cells −1676Δ−1540/−90 CYP11A1 activity was significantly increased under basal conditions >2-fold (*, P<0.01) and >3-fold following forskolin-treatment (**, P<0.01) conditions, as compared to the full-length −1676 CYP11A construct (Fig. 3B). This evidence concerns the gene CYP11A1 and polycystic ovary syndrome.