CYP11A1 and polycystic ovary syndrome: To determine whether the sequence between −160 to −90 bp of CYP11A1 promoter are necessary for increased basal regulation in PCOS theca cells, we constructed −1676 CYP11A1 promoter constructs in which sequences between −160 to −90 bp (−1676 Δ−160/−90) were deleted (Fig. 3A).