ACE2 and hypertrophic cardiomyopathy: Moreover, 2 independent ACE2 polymorphism studies indicated that genetic variants in the ACE2 gene may be associated with LV mass and LV hypertrophy in hemizygous men [24], and minor alleles of ACE2 gene might be the genetic modifier for the magnitude of LV hypertrophy in male patients with hypertrophic cardiomyopathy [25].