This method of filtering has been used to successfully identify disease-causing mutations, including recently by Willemsen et al to identify mutations in DYNC1H1 that cause severe intellectual disability with neuronal migration defects and by Daoud et al to identify mutations in SPG11 that cause juvenile amyotrophic lateral sclerosis [28], [29]. This evidence concerns the gene SPG11 and juvenile amyotrophic lateral sclerosis.