In contrast to controls, in both 11- (3 months after epilepsy induction; images not shown) and 14-month (6 months after epilepsy induction) old epileptic 3×Tg-AD mice, BACE1 IR was clearly present in the inner molecular layer of the dentate gyrus (Fig. 1M–O, Q). Here, BACE1 is linked to epilepsy.