Among the 11 discriminatory transcripts, except COL12A1, ten (namely IL8, MMP3, IL1B, CHI3L1, GREM1, IL1RN, CXCL1, CXCL2, CA7 and SLC7A5) are thought to be associated with colorectal carcinogenesis and progression. Here, IL1RN is linked to medical procedure.