The secreted interleukin-like Gro-alpha oncogene (CXCL1) and matrix-metalloproteinase 3 (MMP3) promote tumor initiation and growth (21–22), while chitinase 3 like-1 (CHI3L1) can protect cancer or/and stromal cells against apoptosis [35]. Here, CHI3L1 is linked to neoplasm.