Consistent with this, Kaschina et al reported that treatment with C21 significantly improved systolic and diastolic ventricular function in the rat after myocardial infarction, suggesting that direct AT2 receptor stimulation may be a novel therapeutic approach to improve cardiac function after myocardial infarction through anti-apoptotic and anti-inflammatory mechanisms [37]. The gene discussed is AGTR2; the disease is myocardial infarction.