We observed that AT2 receptor stimulation by C21 enhanced not only PPARγ expression but also DNA-binding activity of PPARγ in white adipose tissue of KK-Ay, suggesting that the possible crosstalk between AT2 receptor stimulation and PPARγ activation could be involved in the attenuation of insulin resistance in concert with the regulation of adipocyte differentiation and functions. The gene discussed is PPARG; the disease is Insulin resistance.