However, cyclin D2 and α-inhibin double-knockout mice lived longer than mice lacking α-inhibin alone [69], suggesting that p27Kip1 acts cooperatively with inhibins to negatively regulate granulosa cell proliferation [68]–[69] and cyclin D2 may antagonize the tumor-suppressing actions of p27Kip1. Here, CDKN1B is linked to neoplasm.