TSHR and metabolic dysfunction-associated steatohepatitis: Recently, some heterozygous LOF mutations in the TSHR have been described associated with non-autoimmune subclinical hypothyroidism (NASH) and normal sized/hypoplastic gland; in the affected subjects, the defect was dominantly inherited, cosegregating with monoallelic LOF mutations (Table 2, continued 1, continued 2,).