DRD2 and Parkinson disease: This too finds a precedent; synaptic release of glutamate (and GABA) are suppressed by the activation of presynaptic D2 dopamine receptors in the STN (Baufreton and Bevan, 2008; Cragg et al., 2004; Shen and Johnson, 2000) and in experimental PD AMPA (and GABA) receptor agonists generate larger currents in postsynaptic STN neurons (Shen and Johnson, 2005).