EPCAM and metastatic malignant neoplasm in the lymph nodes: Box plot analysis revealed an increasing trend of Ep-ICD cytoplasm, Ep-ICD nucleus, loss of membranous EpEx as well as ESLI with lymph node metastasis (Figure2A and B) which adds credence to our hypothesis that aggressive behavior in PTMC is characterized by loss of surface EpCAM and accumulation of its intracellular domain Ep-ICD.