The IL18 gene is located on chromosome 11q22.2–22.3 with six exons and five introns [10], and many studies show IL-18 gene promoter polymorphisms are associated with autoimmune diseases (RA and SLE),especially the IL-18 gene rs1946518 and rs187238 polymorphisms. This evidence concerns the gene IL18 and systemic lupus erythematosus.