There were no significant association between SLE and the IL-18 -607A/C polymorphism in all genetic models (additive model: OR=0.684, 95%CI=0.455-1.028; dominant model: OR=0.645,95%CI=0.368-1.130; recessive model: OR=0.672, 95%CI =0.447-1.010). This evidence concerns the gene IL18 and systemic lupus erythematosus.