In order to demonstrate functionality of BDD ofVIII to restore the blood coagulation in vivo, hemophilia A mice were injected with either saline or ofVIII at a dose of 300 units/kg, which was determined previously to restore plasma fVIII activity to near endogenous murine levels (2.9 units/ml for C57Bl/6 mice in the colony at Emory University) [1]. The gene discussed is F8; the disease is hemophilia A.