EGFR has been found over-expressed and hyper-activated in human ADPKD epithelia and in mouse models of ADPKD.[3] To investigate whether the upregulated HDAC6 affected EGFR levels in kidney epithelial cells, we inhibited HDAC6 activity with either tubacin or TSA. Here, HDAC6 is linked to autosomal dominant polycystic kidney disease.