FUS and amyotrophic lateral sclerosis: HA-FUS-wt was localized primarily in the nucleus (Fig. 6B, upper panels), however the over-expression of HA-FUS-dC results in the diffused localization pattern with cytoplasmic inclusions (Fig. 6B, middle and bottom panels) like ALS-linked FUS mutants [2], [3], [5], [8], [14].