TARDBP and amyotrophic lateral sclerosis: Additionally mutations in TDP-43 and FUS/TLS gene were identified in the cases of frontotemporal lobar degeneration (FLTD), and ubiquitin-positive inclusions in some cases of FTLD contain these protein products as a major component [2], [9], [10], [11], [12], supporting that ALS and FTLD might be a part of a clinical, pathologic, and genetic disease spectrum.