MDM2 and neuroblastoma: Also consistent with a particular role of the HIPK2-p53 pathway in MYCN-dependent apoptosis, restoring p53 function by p53-MDM2 antagonists seems particularly effective in MNA and MYCN overexpressing NB cells [13], [14] where a further induction of the HIPK2 kinase specifically occurs upon treatment with these drugs [13].