Furthermore, Gal-3 overexpression impaired apoptosis induced by Nut-3 alone or in combination with adriamycin in IMR32 and LAN5 MNA cells (Fig. 6B and Fig. S4), indicating that Gal-3 repression by Nut-3 is linked to its potent apoptotic activity on MNA NB cells. This evidence concerns the gene LGALS3 and neuroblastoma.