In animal models, p53 restoration already proved to be extremely effective in promoting tumor regression [49], [50], [51] and several strategies aimed at restoring p53 function (i.e., p53 gene therapy, wild type p53 restoration via small molecole/MDM2 antagonists and mutant-p53 folding restoration) are being currently tested in clinical trials [52]. The gene discussed is MDM2; the disease is neoplasm.