We previously reported that MDM2-p53 antagonists like Nut-3 effectively induce cell death and synergize with cytotoxic drugs in MNA NB cells by inducing both p53 and its proapoptotic kinase HIPK2, thus enhancing p53 phosphorylation at serine 46 and its commitment towards an apoptotic pathway [13]. Here, HIPK2 is linked to neuroblastoma.