Our study did not detect an association of previously identified autoimmune disease risk SNPs (rs2358817 within VTCN1 gene; rs1049550 within ANXA11 gene; rs6679356 within IL12RB2 gene andrs9865818 within LPP gene) with T1DM in Croatian T1DM trio families. This evidence concerns the gene IL12RB2 and type 1 diabetes mellitus.