AQP3 and Helicobacter pylori infectious disease: We found that AQP3 expression in gastric cancer tissues correlated with H. pylori infection status, and H. pylori upregulated AQP3 expression in human gastric adenocarcinoma cells in vitro via the extracellular signal-regulated kinase (ERK) signaling pathway, confirmed by experimental gastric helicobacter infection in rats.