As shown in Fig. 1A–D, three separate αHS clones (AO4B08, EV3C3, and HS4E4) preferentially stained for HS epitopes localized to the tumor vasculature, i.e. αHS showed strong co-localization with the EC markers von Willebrand factor (vWF) and integrin αvβ3, the latter being a known marker of activated endothelium [28]. This evidence concerns the gene AHSG and neoplasm.